The Rate of Compensatory Evolution
نویسندگان
چکیده
منابع مشابه
The rate of compensatory evolution.
A two-locus model is presented to analyze the evolution of compensatory mutations occurring in stems of RNA secondary structures. Single mutations are assumed to be deleterious but harmless (neutral) in appropriate combinations. In proceeding under mutation pressure, natural selection and genetic drift from one fitness peak to another one, a population must therefore pass through a valley of in...
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Compensatory evolution and the origins of innovations.
Cryptic genetic sequences have attenuated effects on phenotypes. In the classic view, relaxed selection allows cryptic genetic diversity to build up across individuals in a population, providing alleles that may later contribute to adaptation when co-opted--e.g., following a mutation increasing expression from a low, attenuated baseline. This view is described, for example, by the metaphor of t...
متن کاملThe Genomic Landscape of Compensatory Evolution
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially influence directions of adaptive evolution by enabling evolutionary routes that...
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ژورنال
عنوان ژورنال: Genetics
سال: 1996
ISSN: 1943-2631
DOI: 10.1093/genetics/144.1.419